SPHINOX® Defenda

SPHINOX® Defenda

SPHINOX® Defenda

SPHINOX® Defenda is an innovative bioactive sphingolipid that offers a multifunctional product for holistic skin protection. The product has anti- oxidative properties with a special efficacy in DNA protection. Positive effects on sun-stressed skin could be shown in vivo. Overall, this ingredient can protect the skin from sun-induced premature aging.

SPHINOX® Defenda is based on skin-identical Phytosphingosine acylated with an omega hydroxy fatty acid with a short chain length. Such structures fit into the category of omega-hydroxy Ceramides (Ceramide OP).

This ingredient is partly water-soluble and partly soluble in polar emollients.

Preparation of O/W emulsions: This ingredient should be added to the water phase of the emulsion. Then the emulsion is prepared in the usual way. If the addition to the water phase is not possible it is recommended to add the  to the oil phase.

Preparation of W/O emulsions: SPHINOX® Defenda is not compatible with electrolytes typically used for the stabilizing of W/O emulsions like Sodium Chloride or Magnesium Sulfate. Therefore, we recommend to add it to the oil phase. Then the emulsion is prepared in the usual way.

This ingredient might decrease the stability of W/O emulsions. This can be avoided by increasing the concentration of the W/O emulsifier. SPHINOX® Defenda needs to be processed hot.


  • Protecting and soothing face care creams and moisturizer
  • After-sun products
  • Serums and tonics
  • Regenerating and protecting mask
  • Recommended use concentration: 0.02% – 0.2%

Features & Benefits

  • Innovative bioactive sphingolipid
  • Protects the skin from UV induced DNA damage
  • Fights environmental aggressions
  • Accelerates skin regeneration due to DNA protection
  • Daylight defence on a cellular (DNA) level
  • Re-balances skin tone after summer stress

SPHINOX® Defenda













INCI: Hydroxybutyroyl Phytosphingosine (proposed)

AZELIS DISCLAIMER - The information contained herein is given in good faith, based on our current knowledge and without any representation and warranty, express or implied, on its quality, accuracy, and completeness. Although it is our practice to assist our customers with technical advice and to identify and recommend appropriate solutions for any particular application issue, such assistance, advice, and recommendation is provided without guarantee and warranty, express or implied, in relation to the suitability for use, merchantability or performance of a product, formulation or its individual ingredients for any particular application, and we cannot accept any liability for any possible damages, losses or claims in this respect. Considering that we can neither anticipate nor control the different conditions or circumstances under which the product is being used or commercialized, each user should conduct the necessary research and testing to ensure that a product, formulation, or its individual ingredients are fit for purpose and their intended application and verify whether their use or application does not infringe any third party (intellectual property) rights. Users are responsible for ensuring compliance with applicable laws and regulations when handling any product, formulation, or individual ingredient and are expected to familiarize themselves with the Safety Data Sheet for safety, health, and environmental information, including any instructions related to wearing protective equipment. Where required, users should obtain the necessary certifications, permits, and authorizations prior to using or commercializing any product, formulation, or individual ingredient. Please make certain that you are at all times in possession of the latest version of the written technical specification for each product, formulation, or individual ingredient, which can be requested in writing by mailing to your local representative.


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